Testos 250 mg/ml (Testosterone Enanthate)

• Active ingredient: Testosterone Enanthate
• Type: Anabolic steroid (Testosterone derivative)
• Form: Injections

Carrier oil: Grape seed oil

Description

Testosterone is the primary sex hormone in humans, playing a crucial role in the development of male reproductive tissues such as testes and prostate, as well as in females. It also promotes secondary sexual characteristics like increased muscle and bone mass and body hair in males. Testosterone is involved in overall health, well-being, and the prevention of osteoporosis in both sexes. Insufficient levels of testosterone in men may lead to conditions such as frailty and bone loss. Besides, testosterone exhibits pronounced anabolic properties, including increased muscle mass, accelerated protein synthesis, enhanced recovery, and improved glycogen supply to muscles. Testosterone controls numerous processes in the body, making it the most common hormone that is essential for various purposes. It is used not only by elderly individuals with age-related hypogonadism but also by athletes during steroid cycles as a foundational compound.

Mechanism of action

Testosterone binds to androgen receptors and serves as a precursor to dihydrotestosterone, another biologically active androgen formed through the conversion of testosterone by the enzyme 5α-reduction. Dihydrotestosterone exhibits five times greater affinity to androgen receptors. These hormones induce changes in the receptor's structure, transmitting signals to the cell nucleus, where androgenic effects are realized by modifying the activity of specific DNA genes. Testosterone can also convert to estrogen through aromatase activity, primarily estrogens, which activate feedback through the hypothalamus-pituitary-testes axis and suppress endogenous testosterone secretion when exogenous testosterone is administered.

Medical Use

Testosterone is included in the World Health Organization's list of essential medicines, highlighting its importance as a medication in basic healthcare systems. It is utilized for treating gender dysphoria, male hypogonadism, and certain types of breast cancer. As testosterone levels decline with age, hormone replacement therapy (HRT) or testosterone replacement therapy (TRT) becomes necessary to maintain health and quality of life. HRT keeps serum testosterone levels within the normal range. The decline in testosterone production due to aging has led to an increased interest in androgen replacement therapy. Testosterone plays a role in mood, spatial ability, attention, memory, and other cognitive functions in humans. Initial evidence suggests that low testosterone levels are a risk factor for cognitive decline, including Alzheimer's dementia.

In both sexes, testosterone contributes to overall health, well-being, and the prevention of osteoporosis. In men, insufficient testosterone levels can lead to frailty, bone loss, and sexual dysfunction. Therefore, testosterone treatment is beneficial for adult men with age-related low testosterone levels who experience sexual dysfunction.

Testosterone for seniors

Men over 35 who report reduced well-being are often advised to undergo a blood testosterone test. If their levels fall below 12 nmol/L, they may be recommended to start hormone replacement therapy. This decision offers several positive aspects. It improves body composition, increasing muscle mass and reducing fat. Sexual function experiences rejuvenation, and a certain anti-aging effect is observed, reversing the negative effects of androgen deficiency. However, it is essential to consult a doctor and monitor lipid profile, general blood parameters, estradiol levels, and prolactin levels regularly.

It is equally important to note that natural gonadotropin production steadily approaches zero with HRT. Therefore, if fertility is desired, special therapy involving gonadotropins is necessary.

The selection of testosterone therapy dosage should be done in consultation with a doctor. The dosage depends on the individual's normal testosterone levels, current levels, body weight, body fat percentage, sex hormone-binding globulin (SHBG) levels, and the aromatization process.

Approximate dosages for replacement therapy are significantly lower than those used by athletes, ranging from 50-200 mg per week.

Testosterone in sports

The primary advantage of testosterone is its ability to increase muscle mass and strength. It possesses both anabolic and androgenic effects. Androgens enter cells and interact with androgen receptors (AR) proteins. This interaction triggers a change in the shape of the AR protein, activating it. Although this change is minor, it allows the AR to enter the nucleus and bind to DNA, initiating gene transcription.

Rapid weight gain associated with testosterone is attributed to significant water retention due to sodium retention and estrogenic effects. Testosterone can help alleviate joint problems, pain, and cracking in the shoulders and knees, although nandrolone and growth hormone are often preferred in this regard. Testosterone stimulates the body's regeneration processes, enhances overall vitality and motivation for exercise, and prevents overtraining. It also increases oxygen capacity and nitric oxide production, leading to a better pump during training sessions.

The recommended dosage in sports ranges from 250-500 mg per week, with an upward adjustment as the athlete's body weight increases. Testosterone cycles typically last 8-10 weeks, followed by a post-cycle therapy after 2-3 weeks. Testosterone is often used for extended periods of time. In high-level professional athletes, the maximum dosage is 2000 mg per week, as further increases would be ineffective and only increase the risk of side effects.

To prevent the development of estrogenic side effects resulting from the aromatization process, it is highly desirable to conduct tests and use aromatase inhibitors. It is optimal to test estradiol levels before and during the use of aromatase inhibitors to monitor effectiveness and determine the required dosage. It is strongly recommended to rely on professionals for dosage selection, and the information provided below is solely for reference purposes.

Dosages

• Beginner: 250 mg per week
• Average dosage: 300-750 mg per week
• High dosage: 750+ mg per week

Effects

• Increased muscle mass
• Development of male genital organs and secondary sexual characteristics (e.g., deep voice, male facial features, male-pattern hair growth)
• Promotion of spermatogenesis and male behavior (e.g., sexual drive, aggressiveness, decisiveness)
• Burning fat
• Increase in strength
• Enhanced libido
• Reduced blood cholesterol levels
• Reduced risk of heart ischemia and coronary heart disease
• Stimulation of erythropoiesis and male-like distribution of subcutaneous fatty tissue
• Influence on nitrogen and phosphorus metabolism

Side effects

• Increased blood pressure
• Increased sexual behavior
• Hemoconcentration (increased blood clotting)
• Possibility of blood clots in arterial and venous vessels
• Water retention (edema)
• Masculinization
• Aggression, agitation, irritability
• Alopecia (baldness of the scalp)
• Acne
• Insomnia (rare)

Profile

• Half-life: 4-5 days
• Injection frequency: 4-7 days

Pharmaceutical form

• Oily solution for intramuscular injection

Contraindications

• Pregnancy
• Known or suspected prostate or breast carcinoma
• Breastfeeding
• Hypersensitivity to the active substance or any excipients

Storage

• Do not use after the expiration date
• Store between 8ºC and 30ºC
• Do not freeze
• Protect from light