Liothymed 25 mcg (T3 - Triiodothyronine)

• Active ingredient: Triiodothyronine
• Type: Thyroid
• Form: Oral (pills)

Description

Triiodothyronine is a thyroid hormone containing iodine that serves two essential functions. In growing bodies, it is crucial for normal development, especially the central nervous system. In adults, it regulates metabolism and influences nearly all organs and tissues, controlling energy expenditure, speed, and volume.

The thyroid gland stores significant reserves of thyroid hormones to fulfill these functions. While the liver primarily metabolizes thyroid hormones, some conversion also occurs in target tissues such as the brain. The adenohypophysis finely regulates the plasma levels of thyroid hormones using TSH (thyroid-stimulating hormone) and negative feedback mechanisms. TSH signals the production of thyroid hormones, with the primary hormone being T4, which can convert to the active T3 in tissues.

Thyroid hormones primarily act through intracellular receptors, which impact the expression of specific genes.

Mechanism of Action

According to current understanding, T3 binds to intracellular receptors, altering their affinity for T3-sensitive regulatory elements that control gene expression. This modulation of gene expression affects protein synthesis. Typically, a free receptor binds to a regulatory element, suppressing the expression of the corresponding gene, although activation can occur in some cases. By binding to the receptor, T3 enhances or suppresses gene expression. T4 also binds to these receptors, but with lower affinity compared to T3. However, the effect of T4 on gene expression has not been demonstrated, making it functionally a prohormone since its conversion to T3 accounts for its impact on gene expression.

Effective treatments are available for most thyroid conditions, and substitution therapy is commonly used to treat hypothyroidism.

In medical practice, T4 is typically prescribed. However, in sports, both T3 and T4 are used for different purposes.

Liothymed specifically activates the production of beta-2 adrenergic receptors in adipose tissues. The enzyme hormone-sensitive lipase (HSL) plays a crucial role in lipolysis. HSL activity requires adrenaline and norepinephrine (catecholamines). Liothymed stimulates beta-2 receptors, enhancing the ability of catecholamines to activate HSL and promote lipolysis.

Purposes of Use

Triiodothyronine (T3), or liothyronine, is primarily a thyroid hormone with fat-burning effects. It can also impact anabolic processes and stimulate growth hormone (GH) production, contributing to increased anabolism in the body. Liothymed is commonly used for weight loss and shares a similar mechanism of action with thyroxine. However, T3 exhibits a more potent influence on protein catabolism pathways compared to T4. When both substances are used for fat loss, T3 has a greater propensity to reduce muscle mass than T4. Notably, T3 is an active form of T4, as it results from the conversion of thyroxine.

T3 also promotes skeletal muscle growth by increasing the number and diameter of muscle fibers. It plays a role in the transition from neonatal to adult myosin isoforms.

Liothymed for Athletic Purposes

Athletes utilize liothymed to enhance their metabolic processes, resulting in accelerated carbohydrate, protein, and fat conversion. It is particularly sought after for its fat-burning properties. Liothymed is often combined with various anabolic steroids to achieve a more potent anabolic effect, leading to increased muscle mass. When used correctly, liothymed can help achieve a balanced physique with substantial and strong muscles.

How to Use

Typically, the initial dosage of liothymed starts at 25 mcg per day and is increased by 25 mcg every 5-6 days, up to a maximum of 100 mcg per day. The daily dose should be divided into multiple administrations throughout the day. The maximum recommended cycle duration is seven weeks, with at least six weeks between cycles. This approach ensures the normalization of thyroid gland function. Combining liothymed with clenbuterol can further enhance fat-burning effects.

• Average dose: 25 to 100 mcg per day
• Effective dosage: pyramidal method (25-50-75-100-75-50-25)
• Proven cycle duration: 5-6 weeks

Effects

• Regulation of metabolism
• Increased fat burning
• Enhanced anabolic processes and muscle growth

Warnings

• Without anabolic assistance, T3 usage can lead to significant muscle loss.
• Liothyronine may cause an increase in blood sugar levels, potentially affecting glucose tolerance and worsening diabetes. Individuals with diabetes should closely monitor their blood sugar levels and inform their doctor of any abnormalities.
• Starting liothyronine treatment may place additional strain on the heart, particularly in individuals with angina or other heart conditions. It is important for individuals with heart conditions to consult their pharmacist regarding the effects of liothyronine on their specific condition, dosing considerations, and the need for special monitoring.
• Liothyronine is safe for use during pregnancy.
• Liothyronine passes into breast milk in small amounts. Breastfeeding individuals should continue using thyroid hormone and inform their pharmacist about breastfeeding plans or ongoing breastfeeding while using liothyronine.
• Elderly individuals may be more sensitive to the effects of liothyronine and should be cautious of potential adverse effects, particularly those related to the heart.

Side Effects

• Chest pain, discomfort, or tightness
• Difficulty swallowing
• Extreme fatigue
• Fainting
• Fast, slow, irregular, pounding, or racing heartbeat or pulse
• Heat intolerance
• Nausea
• Sweating
• Tremors

Profile

• Half-life: 6-24 hours
• Frequency of intake: 1-2 times per day

Contraindications

• Contraindicated in patients with untreated subclinical (suppressed serum TSH level with normal T3 and T4 levels) overt thyrotoxicosis of any etiology and in patients with acute myocardial infarction.

Storage

• Keep away from children
• Store in a cool, dry place, away from direct sunlight
• Store at room temperature
• Do not use after the expiry date