Propios 100 mg/ml (Testosterone Propionate)

• Active ingredient: Testosterone Propionate
• Type: Anabolic steroid (Testosterone derivative)
• Form: Injections

Carrier oil: Sesame oil

Description

Testosterone is the primary sex hormone in both men and women and plays a crucial role in the development of reproductive tissues, secondary sexual characteristics, and overall health. It promotes increased muscle and bone mass, body hair growth, and contributes to general well-being. Testosterone, with its anabolic properties, enhances muscle growth, accelerates protein synthesis, and aids in glycogen supply to muscles. It is a vital hormone for various bodily processes, used in hormone replacement therapy (HRT) for age-related hypogonadism in the elderly and as a foundation in steroid cycles for athletes.

Mechanism of Action

Testosterone binds to androgen receptors and serves as a precursor to dihydrotestosterone, an active androgen formed through 5α-reduction. Dihydrotestosterone has a stronger binding affinity to androgen receptors. Interaction between these hormones leads to structural changes in the receptors, transmitting signals to the cell nucleus where androgenic effects are realized by altering DNA gene activity. Testosterone can also convert to estrogen through aromatization. Estrogens, rather than testosterone, primarily activate feedback via the hypothalamus-pituitary-testes axis and suppress endogenous testosterone secretion when exogenous testosterone is administered.

Medical Use

Testosterone is included in the World Health Organization's list of essential medicines as it is a vital medication used to treat gender dysphoria, male hypogonadism, and specific types of breast cancer. HRT and testosterone replacement therapy (TRT) are employed to maintain testosterone levels within the normal range and address age-related declines in testosterone production.

Testosterone plays a role in cognitive functions such as mood, spatial ability, attention, memory, and may be a risk factor for cognitive decline and Alzheimer's disease.

Furthermore, testosterone is essential for overall health, well-being, and the prevention of osteoporosis in both sexes. In men, insufficient testosterone levels can lead to abnormalities including frailty and bone loss. Testosterone treatment is beneficial for adult men with age-related low testosterone levels and sexual dysfunction.

Testosterone for Seniors

Men over 35 experiencing a decline in well-being are often recommended to check their testosterone levels. If levels fall below 12 nmol/L, hormone replacement therapy may be offered. This decision has several positive aspects. Body composition improves with increased muscle mass and reduced fat, sexual function is revitalized, and there is a rejuvenating effect. In general, the body recovers from the negative impacts of androgen deficiency.

Close monitoring by a doctor is necessary. Regular assessments of lipid profiles, general blood parameters, estradiol levels, and prolactin levels are important.

It's worth noting that natural gonadotropin production approaches zero during HRT. Therefore, if the desire for offspring arises, specialized therapy with the use of gonadotropins becomes necessary.

Consultation with a healthcare professional is essential for determining the appropriate testosterone therapy dosage. The dosage depends on factors such as baseline testosterone levels, current levels, body weight, body fat percentage, sex hormone-binding globulin (SHBG) levels, and aromatization process.

For replacement therapy, approximate dosages are significantly lower than those used by athletes, typically ranging from 50 mg every other day for beginners to 100-150 mg every other day for average users.

Testosterone in Sports

The primary advantage of testosterone in sports is its ability to increase muscle mass and strength. It has a potent anabolic effect and a strong androgenic effect. Testosterone binds to and activates the androgen receptor (AR) protein, leading to changes in DNA binding and gene activation.

Rapid weight gain associated with testosterone use is partly due to water retention through sodium retention and estrogenic effects. Testosterone can alleviate joint problems, pain, and cracking in the shoulders and knees, although other substances like nandrolone and growth hormone may be preferable in this regard. Testosterone enhances the body's regenerative processes, increases overall vitality and desire for exercise, prevents overtraining, and improves oxygen capacity and nitric oxide production, resulting in better training pump.

For athletes, recommended dosages range from 250-500 mg per week, with adjustments based on body weight. Testosterone cycles typically last 8-10 weeks, followed by a post-cycle therapy period after 2-3 weeks. In some cases, testosterone is used for longer durations. The maximum recommended dosage for high-level professional athletes is typically around 2000 mg per week, as further increases only amplify side effects.

To prevent estrogenic side effects resulting from aromatization, regular testing and the use of aromatase inhibitors are highly recommended. Monitoring estradiol levels before and during aromatase inhibitor use helps determine the effectiveness and necessary dosage. It is crucial to trust professionals for dosage selection, while the information provided below serves as a reference.

Dosages

• Beginner: 50 mg every other day
• Average dosage: 100-150 mg every other day
• High dosage: 100 mg or more every day

Effects

• Increased muscle mass
• Development of male genital organs and secondary sexual characteristics (e.g., deep voice, male facial features, male-pattern hair growth)
• Spermatogenesis and enhancement of male behavior (e.g., sexual drive, aggressiveness, determination)
• Burning of fat
• Increase in strength
• Boost in libido
• Reduction in blood cholesterol levels
• Lower risk of heart ischemia and coronary heart disease
• Stimulation of erythropoiesis and male-like distribution of subcutaneous fatty tissue
• Influence on nitrogen and phosphorus metabolism

Side effects

• Increased blood pressure
• Increased sexual behavior
• Hemoconcentration (blood clotting)
• Possible blood clots in arterial and venous vessels
• Water retention (edema)
• Masculinization
• Aggression, agitation, irritability
• Alopecia (baldness of the scalp)
• Acne
• Insomnia (rare)

Profile

• Half-life: 20 hours
• Frequency of injections: 1-2 days

Pharmaceutical form

• Oily solution for intramuscular injection

Contraindications

• Pregnancy
• Known or suspected carcinoma of the prostate or breast
• Breastfeeding
• Hypersensitivity to the active substance or excipients

How to store

• Do not use after the expiry date
• Store between 8ºC and 30ºC
• Avoid freezing
• Protect from light