Cypilos 250 mg/ml (Testosterone Cypionate)

• Active ingredient: Testosterone Cypionate
• Type: Anabolic steroid (Testosterone derivative)
• Form: Injections

Carrier oil: Sesame oil

Description

Testosterone is the primary sex hormone in humans and plays a crucial role in the development of reproductive tissues in both males and females. It promotes the growth of secondary sexual characteristics such as increased muscle and bone mass, body hair, and prostate development in males. Testosterone also contributes to overall health, well-being, and the prevention of osteoporosis in both sexes. Inadequate testosterone levels in men can lead to abnormalities, including frailty and bone loss. While testosterone is widely known for its anabolic properties, such as increasing muscle mass and protein synthesis, it is also essential for various physiological processes in the body. Testosterone medications are used not only by athletes during steroid cycles but also by elderly individuals with age-related hypogonadism as a form of hormone replacement therapy.

Mechanism of Action

Testosterone binds to androgen receptors and serves as a precursor to dihydrotestosterone (DHT), which is a biologically active androgen. DHT is formed when testosterone interacts with the enzyme 5α-reductase. DHT exhibits a stronger binding affinity to androgen receptors compared to testosterone. When these hormones bind to receptors, they induce structural changes that trigger a signal transmission to the cell nucleus, where androgenic effects are realized by altering the activity of specific DNA genes. Testosterone can also undergo aromatization, converting to estrogen through the action of aromatase. Estrogens, rather than testosterone itself, predominantly activate feedback through the hypothalamus-pituitary-testes axis, suppressing the secretion of endogenous testosterone when exogenous drugs are administered.

Medical Use

Testosterone is included in the World Health Organization's list of essential medicines due to its vital role in various medical applications. It is used to treat conditions such as gender dysphoria, male hypogonadism, and specific types of breast cancer. Hormone replacement therapy (HRT) or testosterone replacement therapy (TRT) is employed to maintain testosterone levels within the normal range, particularly in aging men. Low testosterone levels have been associated with cognitive decline and certain health issues, making testosterone treatment beneficial for adult men with age-related testosterone deficiency and sexual dysfunction. Monitoring the lipid profile, clinical blood parameters, and hormone levels, including estradiol and prolactin, is essential during testosterone therapy. Specialized therapy with gonadotropins may be required for individuals who desire to conceive while undergoing hormone replacement therapy.

Testosterone in Sports

One of the primary advantages of testosterone in sports is its ability to increase muscle mass and strength. It exerts both anabolic and androgenic effects. Androgens enter cells and interact with androgen receptor (AR) proteins, leading to their activation. This activation allows AR to enter the nucleus and bind to DNA, influencing gene expression. Testosterone is also associated with water retention, joint health, pain relief, and the promotion of regeneration processes in the body. It enhances overall tone, exercise motivation, and oxygen capacity in the blood, leading to improved performance during training. In sports, testosterone is commonly used in dosages ranging from 250 to 500 mg per week, which may be adjusted based on the athlete's body weight. Cycle durations typically span 8 to 10 weeks, followed by post-cycle therapy (PCT) after a 2 to 3-week break. Monitoring estradiol levels and using aromatase inhibitors can help mitigate estrogenic side effects caused by aromatization. It is important to consult professionals for dosage selection and closely follow medical guidance.

Dosages

• Beginner: 250 mg per week
• Average dosage: 300-750 mg per week
• High dosage: 750+ mg per week

Effects

• Increased muscle mass
• Development of male genital organs and secondary sexual characteristics
• Promotes spermatogenesis and male behavior (sexual, aggressiveness, resoluteness)
• Burning fat
• Increased strength
• Enhanced libido
• Reduction of blood cholesterol levels
• Decreased risk of heart ischemia and coronary heart disease
• Stimulation of erythropoiesis and male-like distribution of subcutaneous fatty tissue
• Influences nitrogen and phosphorus metabolism

Side effects

• Increased blood pressure
• Heightened sexual behavior
• Hemoconcentration (blood clotting)
• Possible formation of blood clots in arterial and venous vessels
• Water retention (edema)
• Masculinization
• Aggression, agitation, irritability
• Alopecia (scalp baldness)
• Acne
• Insomnia (rare)

Profile

• Half-life: 6-8 days
• Frequency of injections: Every 5-7 days

Pharmaceutical Form

• Oily solution for intramuscular injection

Contraindications

• Pregnancy
• Known or suspected carcinoma of the prostate or breast
• Breastfeeding
• Hypersensitivity to the active substance or any of the excipients

Storage

• Do not use after the expiry date
• Store between 8ºC and 30ºC
• Do not freeze
• Protect from light