Andriolos 250 mg/ml (Testosterone Undecanoate) 10ml vial

• Active ingredient: Testosterone Undecanoate
• Type: Anabolic steroid (Testosterone derivative)
• Form: Injectable

Description

Testosterone Undecanoate is a primary sex hormone found in humans, playing a crucial role in the development of reproductive tissues and promoting secondary sexual characteristics such as increased muscle and bone mass. It also contributes to overall health and well-being, and helps prevent conditions like osteoporosis. Testosterone Undecanoate exhibits pronounced anabolic properties, including muscle mass increase, accelerated protein synthesis, enhanced recovery rate, and improved glycogen supply to muscles. It is a vital hormone that is utilized in hormone replacement therapy for age-related hypogonadism and in sports as a foundational steroid.

Mechanism of Action

Testosterone Undecanoate binds to androgen receptors, serving as a precursor to the biologically active androgen dihydrotestosterone, which is formed through the conversion of testosterone by the enzyme 5α-reduction. Dihydrotestosterone exhibits a five-fold greater affinity for androgen receptors. When testosterone and dihydrotestosterone interact with receptors, they initiate signaling to the cell nucleus, where androgenic effects are mediated by altering the activity of specific DNA genes. Testosterone can be converted to estrogen via the aromatase enzyme. Estrogens, rather than testosterone, predominantly activate feedback through the hypothalamus-pituitary-testes axis, leading to suppression of endogenous testosterone secretion during exogenous testosterone administration.

Medical Use

Testosterone Undecanoate is included in the World Health Organization's list of essential medicines due to its importance in healthcare. It is used to treat conditions such as gender dysphoria, male hypogonadism, and certain types of breast cancer. Hormone replacement therapy is recommended for men with age-related low testosterone levels to maintain health and quality of life. Testosterone replacement therapy ensures serum testosterone levels remain within the normal range. The decline of testosterone production with age has sparked interest in androgen replacement therapy.

Cognitive functions, including mood, spatial ability, attention, and memory, are influenced by testosterone in humans. Lower testosterone levels have been associated with cognitive decline and a potential risk factor for Alzheimer's disease.

Testosterone for Seniors

Men over 35 experiencing well-being issues are often recommended to have their testosterone levels checked. If levels fall below 12 nmol/L, hormone replacement therapy is suggested. This decision yields numerous positive aspects, including improved body composition with increased muscle mass and decreased body fat. Sexual function experiences rejuvenation, leading to an overall rejuvenating effect. However, close monitoring is required, particularly in regard to lipid profiles, general blood parameters, estradiol levels, and prolactin levels.

It is equally important to note that natural gonadotropin production approaches zero during hormone replacement therapy. Therefore, for individuals seeking offspring, special therapy involving gonadotropins is necessary.

Dosage selection for testosterone therapy should be determined through consultation with a medical professional. The dosage depends on factors such as natural testosterone levels, current levels, body weight, body fat percentage, sex hormone-binding globulin (SHBG) levels, and the aromatization process. Replacement therapy dosages are typically lower than those used by athletes, ranging from 50-200 mg per week.

Testosterone in Sports

The primary advantage of testosterone in sports is its ability to increase muscle mass and strength. Alongside its anabolic effects, testosterone also exerts a strong androgenic effect. Androgens interact with androgen receptors, resulting in receptor activation and subsequent binding to DNA. Rapid weight gain is often associated with water retention through sodium retention and estrogenic effects. Testosterone can assist in treating joint problems, relieving pain and improving joint function. It stimulates regeneration processes, increases overall energy and exercise motivation, prevents overtraining, and enhances oxygen capacity and nitric oxide production for better pumps during training.

Recommended dosages in sports range from 250-500 mg per week, with higher dosages often used by athletes with increased body weight. Testosterone cycles typically last 8-10 weeks, followed by a post-cycle therapy period starting 2-3 weeks after the cycle. Prolonged testosterone use is not recommended, with high-level professional athletes rarely exceeding a maximum dosage of 2000 mg per week due to limited benefits and increased side effects.

To prevent the development of estrogenic side effects resulting from aromatization, regular tests and the use of aromatase inhibitors are highly recommended. Monitoring estradiol levels and adjusting the dosage of aromatase inhibitors accordingly is optimal. It is crucial to seek professional guidance for dosage selection; however, the following information is provided for reference purposes.

How to Use

In strength sports, Testosterone Undecanoate is not widely used due to its undefined and insufficient effect, extended duration of action, and is primarily used in clinical andrology as hormone replacement therapy for age-related androgen deficiency. Injections are administered at intervals of approximately 7-14 days to maintain serum testosterone levels consistently within the physiological range. The initial loading dose is followed by injections every 10-12 weeks, and the first dosing interval may be shortened to six weeks to achieve steady-state testosterone levels more rapidly.

Effects

• Increased muscle mass
• Development of male genital organs and secondary sexual characteristics
• Spermatogenesis and male behavior (including sexual, aggressiveness, resoluteness)
• Burning fat
• Increased strength
• Reduced blood cholesterol levels
• Lowered risk of heart ischemia and coronary heart disease
• Stimulation of erythropoiesis and distribution of subcutaneous fatty tissue in a male-like pattern
• Influence on nitrogen and phosphorus metabolism

Side Effects

• Increased blood pressure
• Heightened sexual behavior
• Hemoconcentration (blood clotting)
• Potential for blood clots in arterial and venous vessels
• Water retention (edema)
• Masculinization
• Aggression, agitation, irritability
• Alopecia (scalp baldness)
• Acne
• Insomnia (rare)

Profile

• Half-life: 28-34 days
• Frequency of injections: 7-14 days

Pharmaceutical Form

Oily solution for intramuscular injection

Contraindications

• Pregnancy
• Known or suspected carcinoma of the prostate or breast
• Breastfeeding
• Hypersensitivity to the active substance or any excipients

How to Store

• Do not use after the expiry date
• Store between 8°C and 30°C
• Do not freeze
• Protect from light