Andriolos 250 mg/ml (Testosterone Undecanoate)

• Active ingredient: Testosterone Undecanoate
• Type: Anabolic steroid (Testosterone derivative)
• Form: Injectable

Description

Testosterone is a primary sex hormone present in both men and women. It plays a crucial role in the development of reproductive tissues, such as the testes and prostate, as well as in promoting secondary sexual characteristics like increased muscle and bone mass and body hair in males. It also contributes to overall health, well-being, and the prevention of osteoporosis. Insufficient testosterone levels in men can lead to abnormalities, including frailty and bone loss. Testosterone exhibits pronounced anabolic properties, such as increased muscle mass, enhanced protein synthesis, improved recovery rate, and increased glycogen supply to muscles. It regulates numerous processes in the body and is considered one of the most important hormones, used in hormone replacement therapy for aging individuals and as a base compound in steroid cycles for athletes.

Mechanism of action

Testosterone binds to androgen receptors and serves as a precursor to dihydrotestosterone, a biologically active androgen formed through the action of the 5α-reductase enzyme. Dihydrotestosterone has a five-fold higher affinity for androgen receptors. The binding of these hormones to androgen receptors causes structural changes in the receptor, transmitting a signal to the cell nucleus. This activation leads to androgenic effects by influencing the activity of specific DNA genes. Testosterone can also be converted to estrogen through the process of aromatization. Estrogens, rather than testosterone, predominantly activate feedback through the hypothalamus-pituitary-testes axis, suppressing the secretion of endogenous testosterone when exogenous testosterone is administered.

Medical Use

Testosterone is included in the World Health Organization's list of essential medicines due to its importance in maintaining overall health. It is used medically to treat conditions such as gender dysphoria, male hypogonadism, and certain types of breast cancer. Testosterone replacement therapy (TRT) or hormone replacement therapy (HRT) is often prescribed for men with age-related low testosterone levels to maintain their health and quality of life. The decline in testosterone production with age has sparked interest in androgen replacement therapy. Testosterone also plays a role in cognitive functions, and low testosterone levels have been linked to cognitive decline and possibly dementia of the Alzheimer's type.

Testosterone for Seniors

Men over the age of 35 who experience reduced well-being are often advised to test their testosterone levels. If levels fall below 12 nmol/l, hormone replacement therapy may be recommended. This decision offers several benefits, including positive changes in body composition, such as increased muscle mass and reduced fat. It can rejuvenate sexual function and overall vitality. However, close monitoring of lipid profiles, clinical blood parameters, estradiol levels, and prolactin levels is crucial. Additionally, natural gonadotropin production decreases with hormone replacement therapy, so specific therapy using gonadotropins may be necessary for individuals seeking to conceive.

It is essential to consult with a healthcare professional for dosage selection in testosterone therapy. The appropriate dosage depends on individual factors such as normal testosterone levels, current levels, body weight, body fat percentage, sex hormone-binding globulin (SHBG) levels, and aromatization process. Replacement therapy dosages are typically much lower than those used by athletes, ranging from 50-200 mg per week .

Testosterone in Sports

The primary advantage of testosterone in sports is its ability to increase muscle mass and strength. It exerts anabolic effects and has a significant androgenic impact. Androgens enter cells and interact with androgen receptor (AR) proteins, causing them to change shape and become activated. This activation allows AR to enter the nucleus and bind to DNA, influencing gene expression. Testosterone also promotes water retention, leading to rapid weight gain and improved joint health. It enhances regeneration processes, overall energy levels, and oxygen capacity of the blood, resulting in a satisfying pump during training.

The recommended dosage in sports is typically 250-500 mg per week, with adjustments made based on the athlete's body weight. Testosterone cycles typically last 8-10 weeks, followed by a post-cycle therapy after 2-3 weeks. Some athletes may use testosterone for longer periods, but dosages should not exceed 2000 mg per week due to diminishing returns and increased side effects. To minimize estrogenic side effects resulting from aromatization, it is advisable to undergo tests and consider the use of aromatase inhibitors. Dosage selection should be entrusted to professionals, and the information provided below is for reference purposes only.

How to Use

In strength sports, Testosterone Undecanoate is not widely used due to its undefined and insufficient effect and long-lasting action. However, it is commonly used in clinical andrology as hormone replacement therapy for patients with age-related androgen deficiency. The long half-life of Testosterone Undecanoate allows for less frequent injections to maintain stable serum testosterone levels. After an initial loading dose, injections can be administered every 3 months in a 6-week interval, although more frequent administration every 4-5 weeks is often preferred.

Pharmacokinetic studies have demonstrated that testosterone levels return to the physiological range within 3 days after the first administration. With an interval between injections of approximately 10-12 weeks, testosterone concentrations remain consistently within the normal range. The first dosing interval may be reduced to six weeks to achieve steady-state testosterone levels more rapidly.

It is important to follow these recommendations for the administration of Testosterone Undecanoate:

• Administer the first and second doses of Testosterone Undecanoate 4-6 weeks apart.
• Subsequently, maintain an interval between injections of approximately 10-12 weeks.

Effects

• Increased muscle mass
• Development of male genital organs and secondary sexual characteristics
• Supports spermatogenesis and male behavior (sexual, aggressiveness, resoluteness)
• Burning fat
• Increase in strength
• Boosts libido
• Reduces blood cholesterol levels
• Reduces the risk of heart ischemia and coronary heart disease
• Stimulates erythropoiesis and influences the male-like distribution of subcutaneous fatty tissue
• Affects nitrogen and phosphorus metabolism

Side Effects

• Increased blood pressure
• Increased sexual behavior
• Hemoconcentration (blood clotting)
• Potential for blood clots in arterial and venous vessels
• Water retention (edema)
• Masculinization
• Aggression, agitation, irritability
• Alopecia (scalp baldness)
• Acne
• Insomnia (rare)

Profile

• Half-life: 28-34 days
• Frequency of injections: 7-14 days

Pharmaceutical Form

Oily solution for intramuscular injection.

Contraindications

• Pregnancy
• Known or suspected carcinoma of the prostate or breast
• Breastfeeding
• Hypersensitivity to the active substance or any excipients

How to Store

• Do not use after the expiry date
• Store between 8º to 30ºC
• Avoid freezing
• Protect from light