Semaglutide 2mg

• Active ingredient: Semaglutide
• Type: Glucagon-like peptide-1 receptor agonist
• Form: Injections

Description

Semaglutide is a recombinant DNA biotechnology-derived glucagon-like peptide-1 (GLP-1) receptor agonist. It shares 94% homology with human GLP-1 and acts as a selective agonist for GLP-1 receptors. This receptor subtype is responsible for the physiological effects of GLP-1, which regulates glucose levels, appetite, and cardiovascular function.

Mechanism of action

Semaglutide exerts its effects through GLP-1 receptors in the pancreas, brain, heart, blood vessels, immune system, and kidneys. It reduces blood glucose levels and body weight by stimulating insulin secretion, suppressing glucagon secretion, and delaying gastric emptying. The prolonged half-life of semaglutide allows for once-weekly dosing. It binds to albumin, providing sustained action and protection against metabolic degradation. Semaglutide is also stable against cleavage by dipeptidyl peptidase-4.

Purpose to use

Semaglutide aids in weight loss by reducing energy intake, suppressing appetite, improving satiety signals, decreasing hunger signals, and controlling food cravings. It also improves insulin resistance and reduces the preference for high-fat meals. Semaglutide has shown positive effects on plasma lipids, systolic blood pressure, and inflammation. In animal studies, it inhibits the development of atherosclerosis and reduces inflammation in plaques.

How to use

The initial dose is 0.25 mg once a week for the first 4 weeks. At Week 5, the dose may be increased to 0.5 mg once a week. The maximum dose is 2 mg once a week. Injections should be administered subcutaneously or intramuscularly using an insulin syringe.

Effects

• Improved function of pancreatic β-cells
• Reduced concentration of glucagon
• Lowered high blood glucose levels
• Decreased insulin resistance
• Significant decrease in mean systolic blood pressure
• Weight loss mainly from adipose tissue

Side effects

• Diarrhea
• Constipation
• Nausea
• Vomiting
• Abdominal pain
• Heartburn
• Burping

Warnings

If you experience ongoing pain in the upper left or middle stomach, vision changes, fainting, rapid heartbeat, yellowing of the skin or eyes, fever, clay-colored stools, or swelling of the legs, ankles, or feet, seek immediate medical attention.

Storage

• Store at a temperature not exceeding 30°C or between 2°C and 8°C (in the refrigerator) for 56 days
• Avoid freezing
• Keep away from children
• Do not use after the expiry date