Description

Thyroid hormones are the only known biologically active substances that contain iodine. They have two important functions: in a growing body they are necessary for normal development, especially the central nervous system, and in adults they are responsible for the regulation of metabolism, acting on almost all organs and tissues, they regulate energy expenditure, its speed and volume.

To ensure these functions, the thyroid gland contains large reserves of thyroid hormones. Metabolism of thyroid hormones occurs mainly in the liver, but it is partially carried out in target tissues, for example, in the brain. The level of thyroid hormones in plasma is very finely regulated by the adenohypophysis using TSH with the participation of negative feedback mechanisms. TSH serves as a signal for the production of thyroid hormones, the main of which is T4, which can be converted to T3 mainly in tissues.

Thyroid hormones act mainly through intracellular receptors that affect the expression of certain genes.

Purposes of use

Many patients on replacement therapy have difficulty to convert levothyroxine (T4) to triiodothyronine (T3) efficiently, while the body needs both hormones. This may be due to an overload of the liver with toxins or a deficiency in zinc, which is required for the conversion of T4 to T3. There are also other factors that can interfere with the conversion of T4 to T3, including nutrient depletion and excess iodine, which are common root causes.

Because of the longstanding controversy regarding whether hypothyroid patients can be optimally replaced by treatment with T4 alone, dissatisfaction with the outcome of T4 monotherapy remains high, numerous studies have addressed potential benefits of combined therapy of T3 the T4. T3 added to sufficient T4 dosing to normalize serum T4 and TSH, all rendering T3 levels to at least middle-normal range.

This compound thyroid hormone drug prescribed for replacement therapy including conditions after resection of the thyroid gland, radioiodine therapy, and oncological lesions of the organ, or suppressive therapy.

Replacement therapy is prescribed for hypothyroidism of any etiology:

Primary and secondary hypothyroidism, diffuse and mixed euthyroid goiter, subacute and autoimmune thyroiditis, thyroid cancer (after surgical treatment), obesity with hypothyroidism.

Dosage

Initially, small doses are prescribed, with an increase to the therapeutic dose in 3-4 weeks. In patients with cardiac pathology and over 65 years of age, the doses of thyroid hormones are reduced (the risk of side effects from the cardiovascular system). In children, during pregnancy, the need for thyroid hormones increases. To improve adaptation to treatment with thyroid hormones, it is possible to prescribe adreno-blockers.

How to use

Basically, the dosage starts with 1 pill per day and every 5-6 days increases by 1 pill per day. And the maximum is 3 pills mcg per day. Distribute a few tablets throughout the day. The maximum cycle lasts seven weeks. At least six weeks should pass between cycles. In addition, it will return your thyroid gland to normal functioning. It is commonly stacked with clenbutos to make both even more effective at burning fat.

Average dose: 1 to 3 pills per day.
Effective dosage: pyramidal method (1-2-3-3-2-1)
Proven cycle: 5-6 weeks